Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and links to their rpeorts go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type	Study_count
Total_Studies	2187
interventional	1666
Observational	482
Registry	39

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug\|placebo	505
Drug	389
Other	215
Device	167
Behavioral	150
Procedure	59
Device\|Drug	18
Device\|Other	16
Device\|Drug\|placebo	12
Biological\|placebo	11
Diagnostic Test	11
Dietary Supplement	10
Dietary Supplement\|placebo	10
Behavioral\|Other	9
Biological	9
Other\|placebo	9
Drug\|Other	7
Behavioral\|Drug	5
Behavioral\|Device	4
Combination Product	3
Device\|Procedure	3
Dietary Supplement\|Drug	3
Drug\|Other\|placebo	3
Other\|Procedure	3
Radiation	3
Behavioral\|Dietary Supplement\|placebo	2
Biological\|Drug	2
Device\|Drug\|Other	2
Device\|Radiation	2
Diagnostic Test\|Other	2
Dietary Supplement\|Other	2
Drug\|placebo\|Procedure	2
Drug\|Radiation	2
Behavioral\|Biological\|Diagnostic Test	1
Behavioral\|Device\|Procedure	1
Behavioral\|Drug\|placebo	1
Combination Product\|Drug\|placebo	1
Combination Product\|placebo	1
Device\|Other\|Procedure\|Radiation	1
Device\|placebo	1
Diagnostic Test\|Procedure	1
Dietary Supplement\|Other\|placebo	1
Drug\|Genetic\|Procedure	1
Drug\|Other\|placebo\|Procedure	1
Drug\|Other\|Procedure	1
Drug\|placebo\|Radiation	1
Drug\|Procedure	1
Genetic	1
placebo	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	347
United Kingdom	140
NA	106
Germany	93
Canada	73
France	61
China	53
Netherlands	39
Italy	37
Brazil	35
Spain	35
Denmark	32
Belgium	31
Japan	30
Norway	20
Sweden	14
United States\|Canada	14
Switzerland	13
Turkey	13
Taiwan	12
Kyrgyzstan	11
Israel	9
Korea, Republic of	9
Tunisia	9
Australia	8
Poland	8
Ireland	7
Portugal	7
Australia\|New Zealand	6
Greece	6
Hong Kong	6
Austria	5
Netherlands\|United Kingdom	5
United States\|Germany	5
Belgium\|Netherlands	4
Egypt	4
India	4
New Zealand	4
United States\|Australia\|New Zealand	4
Hungary	3
Indonesia	3
Russian Federation	3
Singapore	3
Sweden\|United Kingdom	3
Thailand	3
Argentina	2
Denmark\|Norway\|Sweden	2
Germany\|Spain\|United Kingdom	2
Germany\|Switzerland	2
Germany\|United Kingdom	2
Japan\|	2
Slovenia	2
United States\|Australia\|Canada\|New Zealand	2
United States\|Puerto Rico	2
United States\|United Kingdom	2
Andorra\|Austria\|Belgium\|Bulgaria\|Czech Republic\|Denmark\|France\|Germany\|Hungary\|Italy\|Netherlands\|Poland\|Romania\|Russian Federation\|Spain\|United Kingdom	1
Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|China\|Colombia\|Costa Rica\|Czech Republic\|Denmark\|Estonia\|Finland\|France\|Germany\|Hungary\|Iceland\|India\|Israel\|Italy\|Latvia\|Lithuania\|Mexico\|Netherlands\|Peru\|Philippines\|Poland\|Portugal\|Romania\|Russian Federation\|Slovakia\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey\|United Kingdom\|Venezuela	1
Argentina\|Australia\|Belgium\|Brazil\|Denmark\|Germany\|India\|Philippines\|United Kingdom	1
Argentina\|Australia\|Canada\|Chile\|Czechia\|France\|Greece\|Hungary\|Korea, Republic of\|Netherlands\|Russian Federation\|South Africa\|United Kingdom	1
Argentina\|Australia\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Mexico\|Poland\|Romania\|Russian Federation\|Spain	1
Argentina\|Australia\|Germany\|India\|United Kingdom\|	1
Argentina\|Austria\|Belgium\|Bulgaria\|Canada\|Chile\|China\|Colombia\|Croatia\|Czech Republic\|Denmark\|Estonia\|Finland\|France\|Germany\|Greece\|Guatemala\|Hong Kong\|Hungary\|Iceland\|India\|Italy\|Japan\|Korea, Republic of\|Latvia\|Lithuania\|Mexico\|Netherlands\|Norway\|Philippines\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Sweden\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
Argentina\|Brazil\|Bulgaria\|Chile\|Germany\|Korea, Republic of\|Slovakia\|Spain	1
Argentina\|Brazil\|Canada\|Croatia\|Czech Republic\|Denmark\|Finland\|Germany\|Hong Kong\|India\|Italy\|Korea, Republic of\|Malaysia\|Norway\|Philippines\|South Africa\|Spain\|Sweden\|Thailand\|Ukraine	1
Argentina\|Brazil\|Canada\|Czech Republic\|Denmark\|Finland\|Germany\|Hong Kong\|India\|Italy\|Korea, Republic of\|Malaysia\|Norway\|Philippines\|Romania\|Russian Federation\|South Africa\|Spain\|Sweden\|Thailand	1
Argentina\|Brazil\|Chile\|Dominican Republic\|Ecuador\|Honduras\|Mexico\|Panama	1
Argentina\|Chile\|China\|Taiwan	1
Argentina\|Chile\|Colombia\|Czech Republic\|Denmark\|Ecuador\|Egypt\|Estonia\|France\|Germany\|Hungary\|Israel\|Italy\|Korea, Republic of\|Latvia\|Lithuania\|Netherlands\|Peru\|Romania\|Russian Federation\|Slovakia\|Spain\|Switzerland\|Turkey\|United Kingdom	1
Argentina\|Chile\|Czechia\|Germany\|Hungary\|Norway\|Romania\|Russian Federation\|Spain\|Sweden	1
Argentina\|Chile\|Estonia\|France\|Germany\|Hungary\|Italy\|Peru\|Poland\|Romania\|Russian Federation\|Slovakia	1
Argentina\|Chile\|New Zealand\|South Africa	1
Argentina\|Colombia\|Croatia\|Estonia\|Hungary\|India\|Israel\|Korea, Republic of\|Latvia\|Mexico\|Panama\|Poland\|Russian Federation\|Serbia\|Slovenia\|Turkey\|United Kingdom	1
Argentina\|Colombia\|Italy\|Malaysia\|Mexico\|Netherlands\|Spain\|Switzerland\|United Kingdom	1
Argentina\|France\|Germany\|Italy\|Norway\|Russian Federation\|Ukraine	1
Argentina\|Mexico\|Russian Federation\|Ukraine	1
Australia\|Austria\|Belgium\|Brazil\|Canada\|Denmark\|France\|Germany\|Greece\|Hungary\|Israel\|Italy\|Korea, Republic of\|Netherlands\|Poland\|Russian Federation\|Slovakia\|South Africa\|Spain\|Turkey\|United Kingdom	1
Australia\|Austria\|Canada\|France\|Germany	1
Australia\|Austria\|Canada\|France\|Hungary\|Italy\|Netherlands\|Poland\|Portugal\|Russian Federation\|South Africa\|Spain\|Switzerland\|United Kingdom	1
Australia\|Austria\|Germany\|Ireland	1
Australia\|Belgium\|Brazil\|Bulgaria\|China\|Denmark\|France\|Germany\|Greece\|Hungary\|Italy\|Netherlands\|New Zealand\|Philippines\|Poland\|Russian Federation\|South Africa\|Spain\|Taiwan\|Tunisia\|Turkey\|Ukraine\|United Kingdom	1
Australia\|Belgium\|Bulgaria\|Denmark\|Finland\|Germany\|Greece\|Hong Kong\|Hungary\|Israel\|Malaysia\|Poland\|Romania\|Singapore\|South Africa\|Spain\|Sweden\|Thailand	1
Australia\|Belgium\|Canada\|France\|Germany\|Italy\|Spain\|Turkey	1
Australia\|Bulgaria\|Germany\|Netherlands\|New Zealand\|Romania	1
Australia\|Canada\|France\|Germany\|Hungary\|Poland\|Slovakia\|Spain\|Sweden	1
Australia\|China\|India	1
Australia\|China\|Korea, Republic of\|New Zealand\|Taiwan	1
Australia\|Czech Republic\|Poland\|Russian Federation	1
Australia\|Denmark\|Norway	1
Australia\|Germany\|Netherlands\|New Zealand\|Poland\|South Africa\|Spain	1
Austria\|Belgium\|Bulgaria\|Croatia\|Czech Republic\|Denmark\|Finland\|France\|Germany\|Hungary\|Italy\|Korea, Republic of\|Netherlands\|Poland\|Romania\|Russian Federation\|Slovakia\|South Africa\|Spain\|Sweden\|Ukraine\|United Kingdom	1
Austria\|Belgium\|Bulgaria\|Czech Republic\|Denmark\|Finland\|France\|Germany\|Hungary\|Israel\|Italy\|Latvia\|Lithuania\|Netherlands\|Norway\|Poland\|Portugal\|Romania\|Russian Federation\|Slovakia\|Slovenia\|Spain\|Turkey\|Ukraine\|United Kingdom	1
Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Netherlands\|South Africa\|Spain\|United Kingdom	1
Austria\|Belgium\|Canada\|Germany\|Russian Federation	1
Austria\|Belgium\|Czech Republic\|Denmark\|Estonia\|Germany\|Greece\|Italy\|Latvia\|Lithuania\|Netherlands\|Norway\|Romania\|Russian Federation\|Slovakia\|Slovenia\|Spain\|Sweden\|Ukraine\|United Kingdom\|	1
Austria\|Belgium\|Czechia\|Denmark\|Estonia\|France\|Germany\|Greece\|Hungary\|Ireland\|Italy\|Latvia\|Lithuania\|Norway\|Poland\|Portugal\|Romania\|Russian Federation\|Slovakia\|Slovenia\|Spain\|Sweden\|United Kingdom	1
Austria\|Belgium\|Denmark\|France\|Germany\|Netherlands\|South Africa\|Sweden	1
Austria\|Belgium\|France\|Germany\|Netherlands\|United Kingdom	1
Austria\|Belgium\|Germany\|Italy\|Spain\|United Kingdom	1
Austria\|Bulgaria\|Canada\|Czech Republic\|France\|Germany\|Hungary\|Italy\|Lithuania\|Netherlands\|Poland\|South Africa\|Spain\|United Kingdom	1
Austria\|Canada\|France\|Germany\|Italy\|Russian Federation\|Sweden	1
Austria\|Denmark\|Netherlands\|Norway\|Sweden	1
Austria\|France	1
Austria\|France\|Germany\|Hungary\|Italy\|Spain\|United Kingdom	1
Austria\|France\|Germany\|Israel	1
Bangladesh	1
Belgium\|Bulgaria\|Finland\|Germany\|Hungary\|Israel\|Poland\|Romania\|Russian Federation\|Sweden	1
Belgium\|Bulgaria\|Greece\|Hungary\|Ireland\|Russian Federation\|Slovakia\|Spain\|Turkey\|United Kingdom	1
Belgium\|Canada\|Germany\|Netherlands	1
Belgium\|Canada\|Germany\|Spain\|United Kingdom	1
Belgium\|Czech Republic\|Denmark\|Germany\|Hungary\|Netherlands\|Spain\|Sweden	1
Belgium\|Czech Republic\|Estonia\|Germany\|Hungary\|Korea, Republic of\|Lithuania\|Norway\|Spain	1
Belgium\|Denmark\|Finland\|Germany\|Netherlands	1
Belgium\|Denmark\|Germany\|Hungary	1
Belgium\|Denmark\|Germany\|Netherlands	1
Belgium\|Denmark\|Netherlands\|Romania\|Russian Federation	1
Belgium\|France	1
Belgium\|France\|Germany\|Italy\|Philippines\|Poland\|Russian Federation\|Spain\|Ukraine	1
Belgium\|France\|Japan	1
Belgium\|Germany	1
Belgium\|Greece\|Netherlands\|Switzerland\|United Kingdom	1
Belgium\|Hungary	1
Belgium\|Italy\|Netherlands	1
Belgium\|Sweden	1
Belgium\|United Kingdom	1
Bulgaria	1
Bulgaria\|Argentina\|Austria\|Belgium\|Canada\|Croatia\|Czechia\|Denmark\|Estonia\|Germany\|Greece\|Hungary\|Latvia\|Lithuania\|Netherlands\|Poland\|Romania\|Serbia\|Slovakia\|Spain\|United Kingdom	1
Bulgaria\|China\|Czechia\|Estonia\|Germany\|Greece\|Hungary\|Italy\|Korea, Republic of\|Mexico\|Poland\|Romania\|Russian Federation\|Slovakia\|Ukraine	1
Bulgaria\|Cyprus\|Greece	1
Bulgaria\|Czech Republic\|Hungary\|Poland\|Romania\|Slovakia	1
Bulgaria\|Denmark\|Poland\|Slovakia\|Sweden	1
Bulgaria\|Finland\|Germany\|Hungary\|Slovakia	1
Bulgaria\|France\|Hungary\|Italy\|Poland\|Russian Federation\|Slovakia\|Ukraine	1
Bulgaria\|Germany\|Hungary\|Korea, Republic of\|Latvia\|Lithuania\|Macedonia, The Former Yugoslav Republic of\|Poland\|Romania\|Russian Federation\|Slovakia\|South Africa\|Spain\|Ukraine\|United Kingdom	1
Bulgaria\|Germany\|Hungary\|Poland\|Russian Federation\|United Kingdom	1
Bulgaria\|Germany\|Hungary\|Ukraine	1
Bulgaria\|Germany\|Poland\|United Kingdom	1
Bulgaria\|Japan\|Romania\|Russian Federation\|Ukraine	1
Bulgaria\|Romania\|Russian Federation	1
Bulgaria\|Slovakia	1
Canada\|Belgium\|Denmark\|France\|Germany\|Italy\|Netherlands\|South Africa	1
Canada\|Croatia\|Czech Republic\|Estonia\|France\|Germany\|Guatemala\|India\|Korea, Republic of\|Latvia\|Lithuania\|Philippines\|Poland\|South Africa\|Taiwan	1
Canada\|Denmark	1
Canada\|Denmark\|Netherlands\|Romania\|Ukraine	1
Canada\|France\|Hungary\|India\|Korea, Republic of\|Latvia\|Lithuania\|Romania\|South Africa\|United Kingdom	1
Canada\|France\|Portugal\|Spain	1
Canada\|Germany\|Hungary\|Spain	1
Canada\|Germany\|Netherlands\|Sweden	1
Canada\|Germany\|Spain	1
Canada\|United States\|Australia\|Germany\|Japan\|Korea, Republic of\|Philippines\|Poland\|Russian Federation\|Slovakia\|Taiwan\|Ukraine	1
Chile	1
China\|Hong Kong\|Indonesia\|Korea, Republic of\|Thailand	1
China\|India\|Korea, Republic of\|Philippines	1
China\|Japan\|Korea, Republic of	1
China\|Korea, Republic of	1
China\|Korea, Republic of\|Philippines\|Taiwan	1
China\|Korea, Republic of\|Philippines\|Taiwan\|Thailand	1
China\|Korea, Republic of\|Taiwan	1
Colombia	1
Colombia\|Czech Republic\|Canada\|Denmark\|Finland\|France\|Germany\|Hungary\|Iceland\|India\|Italy\|Peru\|Russian Federation\|Slovakia\|Taiwan	1
Croatia	1
Cyprus	1
Czech Republic\|France\|Germany\|Hungary\|Italy\|Peru\|Poland\|Russian Federation\|South Africa\|Spain\|Ukraine	1
Czech Republic\|Germany\|Hungary\|Korea, Republic of\|Malaysia\|Poland\|Russian Federation\|Taiwan	1
Czech Republic\|Germany\|Hungary\|Poland	1
Czech Republic\|Romania	1
Czechia	1
Czechia\|Denmark\|Germany\|Hungary\|Netherlands\|Poland\|Russian Federation\|Spain	1
Czechia\|Germany\|Greece\|Netherlands	1
Czechia\|Germany\|Hungary\|Romania	1
Czechia\|Hungary	1
Denmark\|Estonia\|Finland\|Italy\|Lithuania\|Slovakia\|Spain\|United Kingdom	1
Denmark\|Finland\|Germany\|Netherlands\|United Kingdom	1
Denmark\|Finland\|Germany\|Norway\|Sweden	1
Denmark\|Finland\|Netherlands\|Norway	1
Denmark\|Finland\|Netherlands\|Norway\|Sweden	1
Denmark\|Germany	1
Denmark\|Germany\|Poland\|Sweden\|United Kingdom	1
Denmark\|Germany\|Sweden\|United Kingdom	1
Estonia\|Finland	1
Estonia\|Finland\|Germany\|Korea, Republic of\|Latvia\|Lithuania\|Netherlands\|New Zealand\|Russian Federation\|Slovenia\|South Africa\|United Kingdom	1
Estonia\|Finland\|Germany\|Netherlands\|Russian Federation\|Slovakia	1
Estonia\|Germany	1
Estonia\|Slovenia\|Spain\|Sweden\|United Kingdom	1
Finland\|Austria\|Denmark\|France\|Slovenia	1
Finland\|Germany\|Netherlands\|Russian Federation\|United Kingdom	1
Finland\|United Kingdom	1
France\|United States\|Colombia\|Egypt\|Guatemala\|Hungary\|Panama\|Slovakia\|Slovenia	1
Germany\|Hungary\|Italy	1
Germany\|Hungary\|Italy\|Spain\|United Kingdom	1
Germany\|Italy\|South Africa\|Switzerland	1
Germany\|Netherlands	1
Germany\|Netherlands\|Russian Federation\|Sweden\|United Kingdom	1
Germany\|Netherlands\|United Kingdom	1
Germany\|New Zealand\|Russian Federation\|Sweden\|United Kingdom	1
Germany\|Poland	1
Germany\|South Africa	1
Germany\|Spain	1
Germany\|United States\|Belgium\|Hungary	1
Germany\|United States\|Bulgaria\|Japan\|Korea, Republic of\|Poland\|Romania\|Russian Federation\|South Africa\|Taiwan\|Ukraine	1
Germany\|United States\|Czech Republic\|Hungary\|India\|Slovakia\|Spain\|Turkey	1
Greece\|United States\|Finland\|Italy\|Portugal\|Sweden\|Turkey\|United Kingdom	1
Hong Kong\|India\|Japan\|Korea, Republic of\|Singapore\|Taiwan	1
Hong Kong\|Korea, Republic of\|Malaysia\|Philippines\|Taiwan	1
Hong Kong\|Korea, Republic of\|Philippines\|Taiwan	1
Hungary\|Slovakia	1
Iceland	1
India\|Japan\|Korea, Republic of\|Philippines\|Poland\|Russian Federation\|Taiwan\|Ukraine\|Vietnam	1
Iran, Islamic Republic of	1
Italy\|Spain\|Sweden	1
Italy\|Switzerland	1
Japan\|United States\|Argentina\|Czechia\|Germany\|Poland\|Romania\|Russian Federation\|Ukraine	1
Korea, Republic of\|United States\|Australia\|Canada\|Japan\|Netherlands\|Romania\|Russian Federation\|Singapore\|Spain\|Turkey	1
Malaysia	1
Netherlands\|South Africa	1
New Zealand\|Thailand\|United Kingdom	1
Norway\|Sweden	1
Pakistan	1
Peru	1
Poland\|United Kingdom	1
Saudi Arabia	1
Slovakia	1
Slovakia\|Ukraine	1
South Africa	1
South Africa\|Estonia\|Germany\|Netherlands\|Romania\|Russian Federation\|Slovakia\|Sweden\|Ukraine	1
South Africa\|United Kingdom	1
Spain\|France\|Germany	1
Spain\|France\|Germany\|Italy	1
Spain\|Sweden	1
Tunisia\|Morocco	1
Ukraine\|United States\|Argentina\|Estonia\|Germany\|Korea, Republic of\|Norway\|Russian Federation\|South Africa\|Sweden	1
United Kingdom\|Germany\|Netherlands\|Spain\|Sweden	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|Chile\|China\|Croatia\|Czech Republic\|Denmark\|Estonia\|Finland\|France\|Germany\|Greece\|Hong Kong\|Hungary\|Iceland\|Italy\|Latvia\|Lithuania\|Malaysia\|Mexico\|Netherlands\|New Zealand\|Norway\|Pakistan\|Philippines\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Singapore\|Slovakia\|South Africa\|Spain\|Sweden\|Taiwan\|Thailand\|Ukraine\|United Kingdom\|	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Croatia\|Czechia\|Denmark\|Finland\|France\|Germany\|Greece\|Guatemala\|Hong Kong\|Hungary\|India\|Ireland\|Italy\|Japan\|Korea, Republic of\|Latvia\|Lithuania\|Malaysia\|Mexico\|Netherlands\|New Zealand\|Norway\|Philippines\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Singapore\|Slovakia\|Slovenia\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom\|Vietnam	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|China\|Colombia\|Croatia\|Denmark\|Finland\|France\|Georgia\|Germany\|Greece\|Guatemala\|Hungary\|India\|Ireland\|Israel\|Italy\|Korea, Republic of\|Latvia\|Lithuania\|Malaysia\|Mexico\|Netherlands\|New Zealand\|Norway\|Panama\|Peru\|Philippines\|Poland\|Portugal\|Puerto Rico\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Tunisia\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|Chile\|China\|Colombia\|Czechia\|Denmark\|Finland\|France\|Germany\|Hong Kong\|Israel\|Japan\|Korea, Republic of\|Netherlands\|New Zealand\|Norway\|Peru\|Philippines\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Singapore\|South Africa\|Spain\|Sweden\|Thailand\|Turkey\|Ukraine\|United Kingdom\|Vietnam	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Czech Republic\|Denmark\|Finland\|France\|Germany\|Greece\|Hong Kong\|Hungary\|Ireland\|Italy\|Japan\|Lithuania\|Malaysia\|Mexico\|Netherlands\|New Zealand\|Norway\|Philippines\|Poland\|Portugal\|Russian Federation\|Singapore\|Slovakia\|Slovenia\|South Africa\|Spain\|Switzerland\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Canada\|Chile\|Germany\|Italy\|New Zealand	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Canada\|Czechia\|Denmark\|France\|Germany\|Greece\|Guatemala\|Hong Kong\|Hungary\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Philippines\|Poland\|Slovakia\|Spain\|Thailand\|Turkey	1
United States\|Argentina\|Australia\|Austria\|Brazil\|Canada\|Chile\|Colombia\|Czechia\|Denmark\|Germany\|Hungary\|Italy\|Japan\|Korea, Republic of\|Netherlands\|New Zealand\|Philippines\|Poland\|Spain\|Sweden\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Belgium\|Brazil\|Bulgaria\|Chile\|Colombia\|Croatia\|Denmark\|France\|Israel\|Mexico\|New Zealand\|Norway\|Peru\|Philippines\|Poland\|Serbia\|Slovenia\|Sweden\|Taiwan\|Thailand\|Turkey\|Ukraine\|Vietnam	1
United States\|Argentina\|Australia\|Bulgaria\|Canada\|Chile\|Czech Republic\|Hungary\|India\|New Zealand\|Poland\|Slovakia\|South Africa\|Sweden\|United Kingdom	1
United States\|Argentina\|Australia\|Bulgaria\|Canada\|China\|Czech Republic\|Denmark\|Estonia\|Finland\|France\|Germany\|Guatemala\|Hungary\|India\|Italy\|Japan\|Korea, Republic of\|Mexico\|Netherlands\|New Zealand\|Portugal\|Russian Federation\|Slovenia\|Turkey	1
United States\|Argentina\|Australia\|Canada\|Chile\|Denmark\|Germany\|Italy\|Mexico\|Netherlands\|Peru\|South Africa\|Spain\|Sweden\|United Kingdom	1
United States\|Argentina\|Australia\|Canada\|Chile\|Denmark\|Germany\|Japan\|Korea, Republic of\|Netherlands\|Romania\|Slovakia\|Taiwan\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Canada\|Chile\|Estonia\|Germany\|Italy\|Mexico\|Netherlands\|Peru\|Philippines\|South Africa\|Sweden\|United Kingdom	1
United States\|Argentina\|Australia\|Canada\|Chile\|Germany\|Korea, Republic of\|Mexico\|Romania\|South Africa	1
United States\|Argentina\|Australia\|Canada\|Chile\|Germany\|Poland\|Russian Federation\|Turkey\|Ukraine	1
United States\|Argentina\|Australia\|Canada\|France\|Germany\|Italy\|Mexico\|Netherlands\|South Africa\|Spain\|Sweden	1
United States\|Argentina\|Australia\|Canada\|Mexico\|New Zealand\|South Africa	1
United States\|Argentina\|Australia\|Colombia\|Denmark\|Germany\|Guatemala\|Mexico\|Philippines\|South Africa\|Spain\|Turkey	1
United States\|Argentina\|Austria\|Canada\|Colombia\|Czech Republic\|Denmark\|Estonia\|Finland\|France\|Germany\|Greece\|Hungary\|India\|Ireland\|Israel\|Italy\|Mexico\|Netherlands\|Peru\|Philippines\|Poland\|Puerto Rico\|Russian Federation\|Slovakia\|South Africa\|Spain\|United Kingdom	1
United States\|Argentina\|Austria\|Canada\|Germany\|Netherlands\|Russian Federation\|Sweden	1
United States\|Argentina\|Brazil\|Canada\|Germany\|Italy\|Portugal\|Russian Federation\|Spain\|Taiwan\|Ukraine	1
United States\|Argentina\|Brazil\|Chile\|Colombia\|Mexico\|Peru\|South Africa\|Venezuela	1
United States\|Argentina\|Brazil\|Chile\|Costa Rica\|Mexico	1
United States\|Argentina\|Bulgaria\|Canada\|Chile\|China\|Czechia\|Denmark\|Finland\|Germany\|Hungary\|Israel\|Italy\|Japan\|Korea, Republic of\|Mexico\|Poland\|Romania\|Russian Federation\|Slovakia\|Spain\|Sweden\|Turkey\|Ukraine	1
United States\|Argentina\|Bulgaria\|Canada\|Chile\|Colombia\|Croatia\|Hong Kong\|Hungary\|India\|Mexico\|Philippines\|Puerto Rico\|Singapore\|Taiwan\|Thailand	1
United States\|Argentina\|Bulgaria\|Canada\|Chile\|Germany\|Hungary\|Korea, Republic of\|Netherlands\|Philippines\|Romania\|South Africa\|Thailand\|United Kingdom	1
United States\|Argentina\|Bulgaria\|Canada\|Czech Republic\|Germany\|Hungary\|Japan\|Poland\|Slovakia\|South Africa\|Spain\|Sweden\|Taiwan	1
United States\|Argentina\|Bulgaria\|Canada\|Denmark\|Hungary\|Mexico\|Poland\|Russian Federation	1
United States\|Argentina\|Bulgaria\|Canada\|Germany\|Hungary\|Romania\|Russian Federation\|Spain	1
United States\|Argentina\|Bulgaria\|Croatia\|Czechia\|Germany\|Hungary\|Poland\|Slovakia\|South Africa\|Spain\|Turkey	1
United States\|Argentina\|Canada\|Chile\|Colombia\|Italy\|Malaysia\|Mexico\|Peru\|Philippines\|Romania\|Russian Federation\|Serbia\|Spain\|Taiwan\|Thailand\|Ukraine	1
United States\|Argentina\|Canada\|Chile\|Denmark\|Estonia\|Germany\|Korea, Republic of\|Mexico\|Peru\|Philippines\|Poland\|Russian Federation\|Slovakia	1
United States\|Argentina\|Canada\|Chile\|Denmark\|France\|Germany\|Italy\|Korea, Republic of\|Romania\|Russian Federation\|South Africa\|Ukraine	1
United States\|Argentina\|Canada\|Chile\|France\|Germany\|Hungary\|Israel\|Italy\|Korea, Republic of\|Mexico\|Netherlands\|New Zealand\|Peru\|Poland\|Russian Federation	1
United States\|Argentina\|Canada\|Chile\|Romania	1
United States\|Argentina\|Canada\|Colombia\|Mexico\|Peru	1
United States\|Argentina\|Canada\|Finland\|France\|Germany\|Hungary\|Italy\|Spain\|United Kingdom	1
United States\|Argentina\|Canada\|Germany\|India\|Italy\|Korea, Republic of\|Puerto Rico\|Spain\|Sweden\|Taiwan\|Turkey	1
United States\|Argentina\|Canada\|Germany\|India\|Italy\|Spain\|Sweden\|Turkey	1
United States\|Argentina\|Chile\|Greece\|Peru\|Romania\|Ukraine	1
United States\|Argentina\|Chile\|Guatemala\|Honduras\|Romania	1
United States\|Argentina\|Chile\|Netherlands\|Peru\|South Africa	1
United States\|Argentina\|Czechia\|Estonia\|Germany\|Korea, Republic of\|Norway\|Ukraine	1
United States\|Argentina\|France\|Greece\|Korea, Republic of\|New Zealand\|Poland\|Russian Federation\|South Africa\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Germany\|Poland\|Romania\|Russian Federation\|Ukraine	1
United States\|Argentina\|Germany\|Russian Federation\|Ukraine	1
United States\|Argentina\|Lithuania\|Slovakia\|United Kingdom	1
United States\|Argentina\|Norway	1
United States\|Australia\|Austria\|Belgium\|Canada\|Denmark\|Germany\|New Zealand\|Poland\|Portugal\|United Kingdom	1
United States\|Australia\|Austria\|Brazil\|France\|Germany\|Hungary\|New Zealand\|Romania\|Russian Federation\|United Kingdom	1
United States\|Australia\|Austria\|Canada\|Finland\|France\|Greece\|Ireland\|Italy\|Netherlands\|New Zealand\|Russian Federation\|South Africa\|Spain\|United Kingdom	1
United States\|Australia\|Austria\|Canada\|Germany\|Greece\|New Zealand\|Norway\|Slovakia\|South Africa\|Sweden	1
United States\|Australia\|Belgium\|Canada\|Czechia\|Estonia\|France\|Greece\|Italy\|Mexico\|Norway\|Peru\|Poland\|Russian Federation\|Spain\|Sweden	1
United States\|Australia\|Belgium\|Canada\|France\|Germany\|Greece\|Netherlands\|Norway\|Russian Federation\|Spain\|Sweden\|Turkey\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Germany\|Hungary\|Israel\|Netherlands\|New Zealand\|Poland\|Spain\|United Kingdom	1
United States\|Australia\|Brazil\|Canada\|China\|Denmark\|Finland\|France\|Germany\|Greece\|Hong Kong\|Hungary\|India\|Ireland\|Italy\|Korea, Republic of\|Lithuania\|Malaysia\|Mexico\|Netherlands\|Norway\|Portugal\|Singapore\|Slovakia\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Turkey\|United Kingdom	1
United States\|Australia\|Bulgaria\|Canada\|France\|Germany\|Guatemala\|Hungary\|Japan\|Philippines\|Poland\|Russian Federation\|Slovakia\|South Africa\|Spain\|Switzerland\|Taiwan\|Turkey\|United Kingdom	1
United States\|Australia\|Canada\|Germany	1
United States\|Australia\|Canada\|Germany\|Korea, Republic of\|Netherlands\|Poland\|Romania\|Spain	1
United States\|Australia\|China\|Germany\|New Zealand\|Taiwan	1
United States\|Australia\|Denmark\|Finland\|Hungary\|New Zealand\|Poland\|Sweden	1
United States\|Austria\|Belgium\|Brazil\|Canada\|China\|Colombia\|Croatia\|Germany\|Hungary\|India\|Ireland\|Japan\|Norway\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Sweden\|Taiwan\|Turkey\|United Kingdom	1
United States\|Austria\|Belgium\|Canada\|Colombia\|Denmark\|Finland\|France\|Germany\|Greece\|Hungary\|Israel\|Italy\|Mexico\|Norway\|Poland\|Russian Federation\|Slovakia\|Spain\|Switzerland\|Turkey\|United Kingdom	1
United States\|Austria\|Canada\|Czechia\|Germany\|Hungary\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Poland\|Romania\|Russian Federation\|South Africa\|Spain\|Switzerland\|United Kingdom	1
United States\|Austria\|Netherlands\|United Kingdom	1
United States\|Belgium\|Canada\|Czech Republic\|Denmark\|Finland\|Germany\|South Africa\|Spain\|United Kingdom	1
United States\|Belgium\|Canada\|Czech Republic\|Germany\|Greece\|Netherlands\|Portugal\|Ukraine\|United Kingdom	1
United States\|Belgium\|Canada\|Czechia\|Germany\|Hungary\|Netherlands\|Poland\|Romania\|Russian Federation\|United Kingdom	1
United States\|Belgium\|Canada\|Denmark\|Germany\|Hungary\|Netherlands	1
United States\|Belgium\|Canada\|Denmark\|Italy\|Spain	1
United States\|Belgium\|Canada\|Germany	1
United States\|Belgium\|Canada\|Germany\|Netherlands	1
United States\|Belgium\|Denmark\|Estonia\|France\|Germany\|Hungary\|Japan\|Netherlands\|Norway\|Philippines\|Slovakia\|Sweden\|Ukraine	1
United States\|Belgium\|Germany\|Hungary\|Netherlands\|Poland\|Spain	1
United States\|Belgium\|Netherlands	1
United States\|Belgium\|New Zealand	1
United States\|Belgium\|Spain	1
United States\|Bulgaria\|Argentina\|Australia\|Austria\|Belarus\|Belgium\|Bosnia and Herzegovina\|Canada\|Chile\|China\|Colombia\|Croatia\|Czechia\|France\|Georgia\|Germany\|Greece\|Hungary\|India\|Indonesia\|Israel\|Italy\|Japan\|Korea, Republic of\|Latvia\|Macedonia, The Former Yugoslav Republic of\|Malaysia\|Mexico\|Netherlands\|Philippines\|Poland\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom\|Vietnam	1
United States\|Bulgaria\|Canada\|Chile\|Czechia\|Greece\|Japan\|Mexico\|Poland\|Russian Federation\|South Africa\|Spain\|Thailand	1
United States\|Bulgaria\|Canada\|France\|Hungary\|Russian Federation\|Ukraine	1
United States\|Bulgaria\|Czech Republic\|Hungary\|Latvia\|Lithuania\|Philippines\|Poland\|Ukraine\|United Kingdom	1
United States\|Bulgaria\|Czechia\|Germany\|Hungary\|Israel\|Poland\|Spain\|Ukraine\|United Kingdom	1
United States\|Bulgaria\|Czechia\|Germany\|Hungary\|Italy\|Latvia\|Poland\|Romania\|Russian Federation	1
United States\|Bulgaria\|Denmark\|Germany\|Greece\|Hungary\|Iceland\|Mexico\|Romania	1
United States\|Bulgaria\|Estonia\|Germany\|Russian Federation\|United Kingdom	1
United States\|Bulgaria\|Finland\|Hungary\|Puerto Rico\|Romania\|Spain	1
United States\|Bulgaria\|Germany\|Hungary\|Romania\|Russian Federation\|Ukraine	1
United States\|Canada\|Colombia\|Czech Republic\|Hungary\|India\|Netherlands\|Slovakia\|Spain	1
United States\|Canada\|Czechia\|Denmark\|South Africa\|Ukraine\|United Kingdom	1
United States\|Canada\|Czechia\|Germany\|Poland\|Romania	1
United States\|Canada\|Denmark\|France\|Germany\|Israel\|Korea, Republic of\|Netherlands\|Spain\|United Kingdom	1
United States\|Canada\|Denmark\|France\|Germany\|Netherlands\|Romania\|United Kingdom	1
United States\|Canada\|Denmark\|Germany\|Poland\|Spain\|United Kingdom	1
United States\|Canada\|France\|Germany\|Poland\|South Africa	1
United States\|Canada\|France\|Poland\|South Africa\|Spain\|United Kingdom	1
United States\|Canada\|Germany	1
United States\|Canada\|Germany\|Hungary\|Korea, Republic of\|Mexico\|Poland\|Russian Federation\|Spain\|Taiwan	1
United States\|Canada\|Germany\|India\|Italy\|Poland\|South Africa\|Spain	1
United States\|Canada\|Germany\|Korea, Republic of	1
United States\|Canada\|Germany\|Netherlands	1
United States\|Canada\|Germany\|Netherlands\|Spain	1
United States\|Canada\|Philippines\|Poland\|Romania\|Spain\|Ukraine\|Vietnam	1
United States\|Chile\|Czech Republic\|Korea, Republic of\|Poland	1
United States\|Chile\|Estonia\|Germany\|Japan\|Korea, Republic of\|Mexico\|Philippines\|Poland\|Russian Federation	1
United States\|Chile\|Estonia\|Russian Federation	1
United States\|Chile\|Mexico\|Norway\|Romania\|Russian Federation\|South Africa	1
United States\|Chile\|Romania\|Russian Federation\|Slovakia\|South Africa	1
United States\|China\|Czechia\|Germany\|Hungary\|Japan\|Korea, Republic of\|Poland\|Russian Federation\|Taiwan\|United Kingdom	1
United States\|China\|Germany\|Taiwan	1
United States\|Czech Republic\|Germany\|Korea, Republic of	1
United States\|Czech Republic\|Germany\|Poland\|Romania\|South Africa	1
United States\|Czech Republic\|Netherlands\|Poland\|South Africa	1
United States\|Czechia\|Germany	1
United States\|Czechia\|Germany\|Netherlands	1
United States\|Czechia\|Germany\|Poland\|Romania\|Russian Federation	1
United States\|Czechia\|Hungary\|Russian Federation	1
United States\|Estonia\|Germany\|Poland	1
United States\|France\|Germany\|Italy\|Mexico\|Peru\|Poland\|Romania\|Russian Federation\|Ukraine	1
United States\|France\|Germany\|Netherlands\|Spain\|Turkey	1
United States\|France\|Italy\|Spain	1
United States\|Germany\|Italy\|Romania\|United Kingdom	1
United States\|Germany\|Italy\|South Africa\|Spain\|Ukraine	1
United States\|Germany\|Japan	1
United States\|Germany\|Korea, Republic of\|Norway\|Philippines\|Thailand	1
United States\|Germany\|Netherlands\|Norway	1
United States\|Germany\|Romania\|Russian Federation\|Ukraine	1
United States\|Germany\|South Africa	1
United States\|Germany\|Spain\|United Kingdom	1
United States\|Netherlands\|United Kingdom	1
United States\|Poland	1
United States\|Poland\|Russian Federation	1
Vietnam	1

Sites per Study

Site_count	Study_Count
1	924
2	136
3	43
4	41
5	31
6	25
7	15
8	18
9	9
10	15
11	12
12	13
13	10
14	9
15	8
16	6
17	8
18	8
19	10
20	11
21	7
22	3
23	3
24	5
25	7
26	5
27	9
28	4
29	6
30	4
31	7
32	5
33	4
34	5
35	4
36	1
37	5
38	1
39	4
40	6
41	2
42	4
43	5
44	4
45	5
46	1
47	1
48	4
49	4
50	4
51	4
52	3
53	4
54	6
55	5
56	2
57	3
58	1
59	2
60	5
61	2
62	3
64	3
65	1
66	2
67	1
68	3
69	1
70	1
71	1
72	3
73	3
74	1
75	1
76	1
77	1
78	2
79	1
80	1
81	1
83	2
85	1
86	1
88	1
90	2
91	1
92	1
93	2
94	3
95	1
96	2
97	3
98	1
99	1
100	2
101	1
103	2
104	1
105	1
106	1
107	1
110	1
112	3
113	1
114	1
115	1
116	3
118	1
120	3
125	1
126	1
127	1
130	1
132	3
134	1
137	2
138	1
139	1
140	2
143	3
144	1
149	1
157	2
160	1
163	1
165	1
166	2
167	2
170	1
176	1
177	1
178	2
179	1
180	2
183	2
188	1
191	1
197	1
208	1
212	1
213	1
215	1
216	1
222	2
238	1
239	1
240	1
247	1
248	1
270	1
287	1
334	1
338	1
345	2
356	1
409	1
424	1
459	1
468	1
490	1
496	1
544	1
752	1
818	1
999	1
1191	1
1621	1

Phase

Phase	Study_Count
N/A	618
Phase 3	330
Phase 2	259
Phase 4	238
Phase 1	165
Phase 1/Phase 2	27
Phase 2/Phase 3	18
Early Phase 1	11

Number of Arms

Number_of_Arms	Count_of_Studies
1	199
2	887
3	192
4	112
5	55
6	40
7	8
8	18
9	4
10	2
11	2
12	4
14	1
16	1
NA	141

Number of Updates

Count of Versions	Count of Studies
1	164
2	193
3	200
4	174
5	151
6	142
7	84
8	88
9	75
10	45
11	39
12	31
13	27
14	15
15	18
16	11
17	17
18	11
19	13
20	9
21	11
22	6
23	11
24	9
25	8
26	8
27	4
28	4
29	4
30	6
31	6
32	5
33	5
34	2
35	3
36	2
37	3
38	5
39	2
40	1
41	1
42	2
43	2
44	3
45	6
46	1
48	3
49	2
50	2
52	1
53	1
54	1
55	4
56	4
57	1
58	2
59	3
61	1
64	1
67	1
73	1
74	1
81	1
88	1
89	1
92	1
103	1
114	1
142	1
145	1
150	1
161	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	13197	1502	8.786285
Contacts/Locations	6597	1298	5.082434
Recruitment Status	2418	1304	1.854294
Study Design	1870	1190	1.571429
None (earliest Version on record)	1666	1666	1.000000
Outcome Measures	1513	871	1.737084
Study Identification	1037	598	1.734114
Arms	985	646	1.524768
Interventions	985	646	1.524768
Sponsor/Collaborators	961	638	1.506270
Eligibility	912	528	1.727273
Study Description	723	506	1.428854
More Information	685	260	2.634615
Oversight	605	496	1.219758
References	511	391	1.306905
Conditions	469	281	1.669039
Results	407	407	1.000000
IPDSharing	297	276	1.076087
Baseline Characteristics	285	173	1.647399
Participant Flow	134	122	1.098361
Reported Adverse Events	124	111	1.117117
Results Submission Events	117	117	1.000000
Documents	63	62	1.016129
2020 Study Status	1	1	1.000000
Quality Control Review has not concludedReturned: March 31	1	1	1.000000

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	5.00000	3.0000	4.00000	15.0000	6.0000	10.0000	14.0000	4.0000
1st Qu.	19.50000	27.0000	16.00000	25.0000	40.0000	29.2500	159.0000	40.0000
Median	34.00000	60.0000	28.00000	34.0000	76.0000	115.5000	457.0000	124.0000
Mean	91.90909	561.6964	40.45732	234.5185	165.2031	272.7222	844.0898	347.8017
3rd Qu.	94.00000	150.0000	45.00000	62.5000	193.2500	180.0000	933.5000	318.0000
Max.	341.00000	197692.0000	420.00000	5000.0000	2080.0000	2059.0000	17183.0000	7376.0000

Trial Group Type

group_type	Group_Count
Experimental	2153
Active Comparator	773
Placebo Comparator	521
No Intervention	207
Other	175
NA	141
Sham Comparator	39

Intervention Model

intervention_model	Study_Count
Parallel Assignment	1009
Crossover Assignment	410
Single Group Assignment	215
NA	13
Factorial Assignment	10
Sequential Assignment	9

Primary Purpose

primary_purpose	Study_Count
Treatment	1176
Supportive Care	113
Basic Science	84
Prevention	69
Health Services Research	59
Other	59
Diagnostic	47
NA	46
Screening	9
Device Feasibility	3
Educational/Counseling/Training	1

Observational Studies

Studies by Country

Country	Study_Count
NA	90
United States	72
United Kingdom	49
Germany	31
France	27
China	23
Canada	17
Spain	16
Italy	12
Taiwan	10
Norway	9
Sweden	9
Greece	8
Japan	8
Korea, Republic of	8
Denmark	7
Russian Federation	6
Belgium	5
Brazil	5
Turkey	5
Ireland	4
Israel	4
Netherlands	4
Switzerland	4
Austria	3
Egypt	3
Kazakhstan	2
Argentina\|Colombia\|Uruguay\|Venezuela	1
Australia	1
Australia\|China\|Korea, Republic of\|Taiwan	1
Australia\|Germany	1
Australia\|New Zealand\|United Kingdom	1
Australia\|United States\|Argentina\|Brazil\|Canada\|China\|Colombia\|Denmark\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Mexico\|Netherlands\|Norway\|Spain\|Sweden\|United Kingdom	1
Austria\|Belgium\|Denmark\|Finland\|France\|Germany\|Greece\|Ireland\|Italy\|Netherlands\|Norway\|Portugal\|Spain\|Sweden\|Switzerland\|Turkey\|United Kingdom	1
Austria\|Czechia\|Hungary\|Israel\|Romania\|Russian Federation\|Slovakia\|Slovenia\|Switzerland	1
Belgium\|Denmark\|Finland\|Germany\|Netherlands\|Norway	1
Belgium\|France\|Germany\|Greece\|Ireland\|Italy\|Netherlands\|Spain\|Sweden	1
Belgium\|France\|Germany\|Netherlands\|Poland\|Spain	1
Belgium\|Greece\|Netherlands\|United Kingdom	1
Bulgaria	1
Bulgaria\|Czechia\|Hungary\|Israel\|Lithuania\|Poland\|Romania\|Russian Federation\|Slovenia\|Switzerland\|Ukraine	1
Bulgaria\|Greece\|Hong Kong\|Korea, Republic of\|Norway\|Slovakia	1
Canada\|France	1
Chile	1
Costa Rica	1
Croatia	1
Czechia	1
Denmark\|France\|Germany	1
Denmark\|France\|Netherlands	1
Denmark\|Germany\|United Kingdom	1
Hong Kong	1
Hungary\|Slovakia\|Slovenia	1
India	1
Israel\|United Kingdom	1
Kyrgyzstan	1
Netherlands\|United Kingdom	1
Poland\|Croatia\|Romania\|Russian Federation\|Slovakia\|Slovenia	1
Qatar	1
Romania	1
Serbia	1
Spain\|Croatia\|Denmark\|Ireland\|Italy\|Netherlands\|Norway\|Portugal\|Sweden\|United Kingdom	1
Thailand	1
Uganda	1
United States\|Belgium\|Canada\|Denmark\|Finland\|Germany\|Japan\|Korea, Republic of\|Poland\|Spain\|Sweden\|United Kingdom	1
United States\|Bulgaria\|Canada\|Czech Republic\|Denmark\|Netherlands\|New Zealand\|Norway\|Slovenia\|Spain\|Ukraine\|United Kingdom	1
United States\|Bulgaria\|Canada\|Czech Republic\|France\|Germany\|Italy\|Russian Federation\|Sweden	1
United States\|Germany\|Italy	1
United States\|Puerto Rico	1

Sites per Study

Site_count	Study_Count
1	348
2	27
3	14
4	6
5	7
6	4
8	5
9	2
10	1
11	1
12	2
13	3
14	1
15	4
17	1
18	1
19	5
20	5
21	1
22	3
23	1
25	1
26	2
28	1
30	1
32	2
40	2
41	1
42	1
44	1
47	2
50	1
51	1
52	1
57	1
60	1
71	1
74	1
79	1
89	1
90	1
108	1
123	1
141	1
169	1
177	1
185	1
188	1
233	1
298	1
352	1
388	1
418	1
605	1
606	1
701	1
864	1

Number of Updates

Count of Versions	Count of Studies
1	79
2	90
3	75
4	63
5	33
6	25
7	18
8	14
9	11
10	7
11	4
12	7
13	5
14	2
15	8
16	6
17	2
18	3
19	3
20	2
21	4
22	3
23	1
24	2
26	2
27	2
29	2
30	2
32	1
36	1
38	1
39	1
43	1
56	1
103	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	2381	403	5.908189
Contacts/Locations	1006	307	3.276873
None (earliest Version on record)	482	482	1.000000
Recruitment Status	482	312	1.544872
Study Design	445	286	1.555944
Study Identification	232	141	1.645390
Eligibility	225	135	1.666667
Outcome Measures	223	127	1.755905
Study Description	200	133	1.503759
Sponsor/Collaborators	189	144	1.312500
Oversight	127	103	1.233010
Groups	106	80	1.325000
Interventions	106	80	1.325000
References	104	74	1.405405
More Information	90	27	3.333333
Conditions	81	54	1.500000
Results	43	43	1.000000
IPDSharing	26	24	1.083333
Baseline Characteristics	22	18	1.222222
Documents	15	15	1.000000
Reported Adverse Events	13	11	1.181818
Results Submission Events	9	9	1.000000
Participant Flow	8	8	1.000000

Enrollment Metrics

Measure	Observational
Min	1.00
1st Qu	80.50
Median	262.50
Mean	10068.25
3rd Qu	1153.75
Max	2100000.00

Observation Model

observational_model	Study_Count
Cohort	281
NA	59
Case-Only	46
Other	31
Case-Control	28
Case Control	25
Case-Crossover	7
Family-Based	3
Defined Population, Natural History	1
Natural History	1

Time Perspective

time_perspective	Study_Count
Prospective	297
Cross-Sectional	83
Retrospective	64
NA	30
Other	5
Cross-Sectional, Prospective	1
Longitudinal, Prospective	1
Longitudinal, Retrospective	1

Registries

Studies by Country

Country	Study_Count
United States	7
China	4
Korea, Republic of	4
Germany	3
United Kingdom	3
Japan	2
Spain	2
Argentina	1
Austria\|Bulgaria\|Croatia\|Czech Republic\|Hungary\|Latvia\|Poland\|Russian Federation\|Serbia\|Slovakia\|Slovenia	1
Austria\|Spain\|Switzerland\|United Kingdom	1
Belgium	1
Brazil	1
France	1
Italy	1
NA	1
Netherlands	1
Russian Federation	1
Sweden	1
Taiwan	1
Tunisia	1
Turkey	1

Sites per Study

Site_count	Study_Count
1	26
2	2
3	2
4	2
6	2
11	1
15	1
23	1
81	1
180	1

Number of Updates

Count of Versions	Count of Studies
1	12
2	6
3	6
4	7
6	1
7	2
8	1
9	1
16	1
22	1
44	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	150	27	5.555556
Contacts/Locations	69	20	3.450000
None (earliest Version on record)	39	39	1.000000
Recruitment Status	36	21	1.714286
Study Design	25	17	1.470588
Outcome Measures	15	13	1.153846
Study Description	10	9	1.111111
Oversight	9	8	1.125000
Groups	7	4	1.750000
Interventions	7	4	1.750000
Eligibility	6	5	1.200000
Sponsor/Collaborators	6	4	1.500000
Study Identification	5	4	1.250000
IPDSharing	4	4	1.000000
References	3	2	1.500000
Conditions	1	1	1.000000
Documents	1	1	1.000000

Enrollment Metrics

Measure	Registries
Min	10.00
1st Qu	117.00
Median	505.00
Mean	88668.03
3rd Qu	3251.00
Max	2500000.00

Registry Model

observational_model	Study_Count
Cohort	26
Case-Control	5
Other	5
Case-Only	2
Case-Crossover	1

Time Perspective

time_perspective	Study_Count
Prospective	23
Other	9
Cross-Sectional	7

Follow-up

target_duration	Study_Count
1 Day	5
3 Years	4
12 Months	3
1 Month	2
1 Year	2
10 Years	2
2 Years	2
20 Years	2
5 Years	2
6 Months	2
8 Years	2
1 Week	1
13 Weeks	1
15 Years	1
18 Months	1
2 Days	1
2 Months	1
2 Weeks	1
24 Weeks	1
4 Years	1
7 Months	1
9 Months	1

intervention_type	Study_Count
Drug\|placebo	505
Drug	389
Other	215
Device	167
Behavioral	150
Procedure	59
Device\|Drug	18
Device\|Other	16
Device\|Drug\|placebo	12
Biological\|placebo	11
Diagnostic Test	11
Dietary Supplement	10
Dietary Supplement\|placebo	10
Behavioral\|Other	9
Biological	9
Other\|placebo	9
Drug\|Other	7
Behavioral\|Drug	5
Behavioral\|Device	4
Combination Product	3
Device\|Procedure	3
Dietary Supplement\|Drug	3
Drug\|Other\|placebo	3
Other\|Procedure	3
Radiation	3
Behavioral\|Dietary Supplement\|placebo	2
Biological\|Drug	2
Device\|Drug\|Other	2
Device\|Radiation	2
Diagnostic Test\|Other	2
Dietary Supplement\|Other	2
Drug\|placebo\|Procedure	2
Drug\|Radiation	2
Behavioral\|Biological\|Diagnostic Test	1
Behavioral\|Device\|Procedure	1
Behavioral\|Drug\|placebo	1
Combination Product\|Drug\|placebo	1
Combination Product\|placebo	1
Device\|Other\|Procedure\|Radiation	1
Device\|placebo	1
Diagnostic Test\|Procedure	1
Dietary Supplement\|Other\|placebo	1
Drug\|Genetic\|Procedure	1
Drug\|Other\|placebo\|Procedure	1
Drug\|Other\|Procedure	1
Drug\|placebo\|Radiation	1
Drug\|Procedure	1
Genetic	1
placebo	1

Count of Versions	Count of Studies
1	164
2	193
3	200
4	174
5	151
6	142
7	84
8	88
9	75
10	45
11	39
12	31
13	27
14	15
15	18
16	11
17	17
18	11
19	13
20	9
21	11
22	6
23	11
24	9
25	8
26	8
27	4
28	4
29	4
30	6
31	6
32	5
33	5
34	2
35	3
36	2
37	3
38	5
39	2
40	1
41	1
42	2
43	2
44	3
45	6
46	1
48	3
49	2
50	2
52	1
53	1
54	1
55	4
56	4
57	1
58	2
59	3
61	1
64	1
67	1
73	1
74	1
81	1
88	1
89	1
92	1
103	1
114	1
142	1
145	1
150	1
161	1

Site_count	Study_Count
1	348
2	27
3	14
4	6
5	7
6	4
8	5
9	2
10	1
11	1
12	2
13	3
14	1
15	4
17	1
18	1
19	5
20	5
21	1
22	3
23	1
25	1
26	2
28	1
30	1
32	2
40	2
41	1
42	1
44	1
47	2
50	1
51	1
52	1
57	1
60	1
71	1
74	1
79	1
89	1
90	1
108	1
123	1
141	1
169	1
177	1
185	1
188	1
233	1
298	1
352	1
388	1
418	1
605	1
606	1
701	1
864	1

Count of Versions	Count of Studies
1	79
2	90
3	75
4	63
5	33
6	25
7	18
8	14
9	11
10	7
11	4
12	7
13	5
14	2
15	8
16	6
17	2
18	3
19	3
20	2
21	4
22	3
23	1
24	2
26	2
27	2
29	2
30	2
32	1
36	1
38	1
39	1
43	1
56	1
103	1

Count of Versions	Count of Studies
1	164
2	193
3	200
4	174
5	151
6	142
7	84
8	88
9	75
10	45
11	39
12	31
13	27
14	15
15	18
16	11
17	17
18	11
19	13
20	9
21	11
22	6
23	11
24	9
25	8
26	8
27	4
28	4
29	4
30	6
31	6
32	5
33	5
34	2
35	3
36	2
37	3
38	5
39	2
40	1
41	1
42	2
43	2
44	3
45	6
46	1
48	3
49	2
50	2
52	1
53	1
54	1
55	4
56	4
57	1
58	2
59	3
61	1
64	1
67	1
73	1
74	1
81	1
88	1
89	1
92	1
103	1
114	1
142	1
145	1
150	1
161	1

Site_count	Study_Count
1	348
2	27
3	14
4	6
5	7
6	4
8	5
9	2
10	1
11	1
12	2
13	3
14	1
15	4
17	1
18	1
19	5
20	5
21	1
22	3
23	1
25	1
26	2
28	1
30	1
32	2
40	2
41	1
42	1
44	1
47	2
50	1
51	1
52	1
57	1
60	1
71	1
74	1
79	1
89	1
90	1
108	1
123	1
141	1
169	1
177	1
185	1
188	1
233	1
298	1
352	1
388	1
418	1
605	1
606	1
701	1
864	1

Count of Versions	Count of Studies
1	79
2	90
3	75
4	63
5	33
6	25
7	18
8	14
9	11
10	7
11	4
12	7
13	5
14	2
15	8
16	6
17	2
18	3
19	3
20	2
21	4
22	3
23	1
24	2
26	2
27	2
29	2
30	2
32	1
36	1
38	1
39	1
43	1
56	1
103	1

pulmonary disease, chronic obstructive

Study Counts

Studies over Time

Interventional Trials

Intervention Type

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Studies by Country

Sites per Study

Phase

Number of Arms

Number of Updates

Update History Change Type

Enrollment Metrics by Phase

Trial Group Type

Intervention Model

Primary Purpose

Observational Studies

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Observation Model

Time Perspective

Registries

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Registry Model

Time Perspective

Follow-up

Count of Versions	Count of Studies
1	164
2	193
3	200
4	174
5	151
6	142
7	84
8	88
9	75
10	45
11	39
12	31
13	27
14	15
15	18
16	11
17	17
18	11
19	13
20	9
21	11
22	6
23	11
24	9
25	8
26	8
27	4
28	4
29	4
30	6
31	6
32	5
33	5
34	2
35	3
36	2
37	3
38	5
39	2
40	1
41	1
42	2
43	2
44	3
45	6
46	1
48	3
49	2
50	2
52	1
53	1
54	1
55	4
56	4
57	1
58	2
59	3
61	1
64	1
67	1
73	1
74	1
81	1
88	1
89	1
92	1
103	1
114	1
142	1
145	1
150	1
161	1

Site_count	Study_Count
1	348
2	27
3	14
4	6
5	7
6	4
8	5
9	2
10	1
11	1
12	2
13	3
14	1
15	4
17	1
18	1
19	5
20	5
21	1
22	3
23	1
25	1
26	2
28	1
30	1
32	2
40	2
41	1
42	1
44	1
47	2
50	1
51	1
52	1
57	1
60	1
71	1
74	1
79	1
89	1
90	1
108	1
123	1
141	1
169	1
177	1
185	1
188	1
233	1
298	1
352	1
388	1
418	1
605	1
606	1
701	1
864	1

Count of Versions	Count of Studies
1	79
2	90
3	75
4	63
5	33
6	25
7	18
8	14
9	11
10	7
11	4
12	7
13	5
14	2
15	8
16	6
17	2
18	3
19	3
20	2
21	4
22	3
23	1
24	2
26	2
27	2
29	2
30	2
32	1
36	1
38	1
39	1
43	1
56	1
103	1